An uncommon variant of Alzheimer’s disease: Posterior cortical atrophy

South African Journal of Psychiatry

 
 
Field Value
 
Title An uncommon variant of Alzheimer’s disease: Posterior cortical atrophy
 
Creator Bux, Tasneem Pillay, Kyle Daya, Reyna Bayat, Zaheer Greenstein, Lara S.
 
Subject Geriatrics; Psychiatry; Neurology posterior cortical atrophy; Alzheimer’s dementia; visuospatial apraxia; neurodegeneration; atypical Alzheimer’s
Description Introduction: This case report highlights one of the less common variants of major neurocognitive disorder because of Alzheimer’s disease, posterior cortical atrophy. There is a paucity of data about this condition in sub-Saharan Africa.Patient presentation: A 54-year-old female presented to the geriatric clinic following a 2-year history of poor memory and inability to fulfil her work obligations. The most prominent symptom was visual disturbance, with a normal ophthalmic examination.Management and outcome: Workup done to reveal reversible causes of dementia did not yield any positive results. After a full history, physical and cognitive examination and radiological investigations, a diagnosis of posterior cortical atrophy variant of major neurocognitive disorder because of Alzheimer’s disease as the most likely aetiology was established.Conclusion: Posterior cortical atrophy is a rare variant of Alzheimer’s disease, and no case reports from South Africa are available in the literature.Contribution: This case reminds us that unusual presentations of cognitive impairment require a broad differential diagnosis.
 
Publisher AOSIS
 
Contributor
Date 2025-05-23
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Case report
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajpsychiatry.v31i0.2420
 
Source South African Journal of Psychiatry; Vol 31 (2025); 4 pages 2078-6786 1608-9685
 
Language eng
 
Relation
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://sajp.org.za/index.php/sajp/article/view/2420/3899 https://sajp.org.za/index.php/sajp/article/view/2420/3900 https://sajp.org.za/index.php/sajp/article/view/2420/3901 https://sajp.org.za/index.php/sajp/article/view/2420/3902
 
Coverage Africa; South Africa; Gauteng — African; female; 52 years old
Rights Copyright (c) 2025 Tasneem Bux, Kyle Pillay, Reyna Daya, Zaheer Bayat, Lara S. Greenstein https://creativecommons.org/licenses/by/4.0
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