Association of obesity with hyperuricaemia among HIV-positive patients on antiretroviral therapy in South-Western Uganda
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Association of obesity with hyperuricaemia among HIV-positive patients on antiretroviral therapy in South-Western Uganda | |
| Creator | Rugera, Simon P. Mudondo, Hope Tumusiime, Jazira Udu, Rahma Kiconco, Ritah Lumumba, Sylvia A. Bagenda, Charles N. | |
| Description | Background: Hyperuricaemia is a risk factor for gout and independently predicts hypertension, diabetes, and chronic kidney disease development. While elevated uric acid levels occur in HIV patients, and weight gain is linked to dolutegravir-based therapy, data on the obesity-hyperuricaemia relationship in this population remain limited.Objective: The objective of our study was to evaluate the association between obesity and hyperuricaemia among HIV-positive patients on antiretroviral therapy in South-Western Uganda.Methods: Between April 2024 and June 2024, this study conducted a secondary analysis of data on uric acid level and factors associated with obesity from a 2023 cross-sectional study of HIV-positive participants. We used logistic regression to assess the factors associated with hyperuricaemia, and receiver operating characteristic curve analysis to assess the predictive performance of body mass index for hyperuricaemia.Results: Among 328 participants, hyperuricaemia prevalence was 23.48% (95% confidence interval [CI]: 19.19–28.39%) higher in male participants (31.6%) than female participants (20.0%, p = 0.023). Overweight (adjusted odds ratio [aOR]: 2.01; 95% CI: 1.01–4.00; p = 0.046), obesity (aOR: 2.50; 95% CI: 1.09–5.73, p = 0.030), and male gender (aOR: 2.31; 95% CI: 1.07–5.01, p = 0.033) were significantly associated with hyperuricaemia.Conclusion: Our findings indicate a relationship between hyperuricaemia and obesity in HIV patients on antiretroviral therapy in Uganda. Nationwide studies using primary data are needed to better understand this relationship’s epidemiological spread.What this study adds: This study is the first to link obesity with hyperuricaemia among HIV-positive Ugandans on antiretroviral therapy, highlighting obesity as a key metabolic complication of HIV treatment. | |
| Publisher | AOSIS | |
| Date | 2025-02-19 | |
| Identifier | 10.4102/ajlm.v14i1.2565 | |
| Source | African Journal of Laboratory Medicine; Vol 14, No 1 (2025); 9 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
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https://ajlmonline.org/index.php/ajlm/article/view/2565/3064
https://ajlmonline.org/index.php/ajlm/article/view/2565/3065
https://ajlmonline.org/index.php/ajlm/article/view/2565/3066
https://ajlmonline.org/index.php/ajlm/article/view/2565/3067
https://ajlmonline.org/index.php/ajlm/article/downloadSuppFile/2565/6688
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