Antipsychotics and chronic dystonia at a Botulinum Toxin clinic

South African Journal of Psychiatry

 
 
Field Value
 
Title Antipsychotics and chronic dystonia at a Botulinum Toxin clinic
 
Creator Thosago, Mahlatse Asmal, Laila
 
Subject Medicine; Psychiatry; Neurology dystonia; Botulinum toxin; antipsychotics; chronic dystonia; tardive dystonia; neuroleptics
Description Background: Chronic dystonia, characterised by sustained muscle contractions and abnormal postures, poses clinical challenges, especially when associated with antipsychotic medication use.Aim: To delineate the demographic and clinical profiles of adults with dystonia and examine the association with antipsychotic medication.Setting: Botulinum Toxin Clinic at Tygerberg Hospital, Cape Town, South Africa.Methods: We conducted a retrospective cohort study of adult patients seen at the Botulinum Toxin Clinic between January 2018 and June 2022.Results: Of the 119 patients studied, those assessed with antipsychotic-induced dystonia (32.69%) presented at a younger age (p  0.001), were more likely female (p = 0.04), received higher average dose of Botulinum toxin (p  0.001), and incurred a higher estimated Botulinum toxin treatment cost (p = 0.01) compared to those with primary dystonia. Logistic regression identified age and Botulinum toxin dose as factors associated with psychotropic-related dystonia (p = 0.005 and p = 0.012, respectively).Conclusion: Clinical and demographic factors are associated with dystonia in adults taking antipsychotic medication. These patients generally manifested symptoms at an earlier age, had a higher male prevalence, and required prolonged treatment with Botulinum toxin, leading to increased costs. In those assessed with antipsychotic-induced dystonia, a comorbid diagnosis of a mood disorder was more common than that of a psychotic disorder.Contribution: By identifying the demographic and clinical profile of individuals with dystonia because of antipsychotic medication, this study provides a basis for preventative strategies and enhanced patient care.
 
Publisher AOSIS
 
Contributor
Date 2024-09-16
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Cohort study
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajpsychiatry.v30i0.2270
 
Source South African Journal of Psychiatry; Vol 30 (2024); 5 pages 2078-6786 1608-9685
 
Language eng
 
Relation
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://sajp.org.za/index.php/sajp/article/view/2270/3522 https://sajp.org.za/index.php/sajp/article/view/2270/3523 https://sajp.org.za/index.php/sajp/article/view/2270/3524 https://sajp.org.za/index.php/sajp/article/view/2270/3525
 
Coverage Africa; South Africa; Western Cape; Cape Town; Estern Metropole January 2018- June 2022 Age; Sex; Dystonia patients
Rights Copyright (c) 2024 Mahlatse Thosago, Laila Asmal https://creativecommons.org/licenses/by/4.0
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