Lessons learnt from assessing and improving accuracy and positive predictive value of the national HIV testing algorithm in Nigeria
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Lessons learnt from assessing and improving accuracy and positive predictive value of the national HIV testing algorithm in Nigeria | |
| Creator | Mpamugo, Augustine O. Iriemenam, Nnaemeka C. Bashorun, Adebobola Okunoye, Olumide O. Bassey, Orji O. Onokevbagbe, Edewede Jelpe, Tapdiyel Alagi, Matthias A. Meribe, Chidozie Aguolu, Rose E. Nzelu, Charles E. Bello, Segun Ezra, Babatunde Obioha, Christine A. Ibrahim, Baffa S. Adedokun, Oluwasanmi Ikpeazu, Akudo Ihekweazu, Chikwe Croxton, Talishiea Adebajo, Sylvia B. Okoye, McPaul I.J. Abimiku, Alash’le | |
| Description | Background: HIV testing remains an entry point into HIV care and treatment services. In 2007, Nigeria adopted and implemented a two-test rapid HIV testing algorithm of three HIV rapid test kits, following the sequence: Alere Determine (first test), UnigoldTM (second test), and STAT-PAK® as the tie-breaker. Sub-analysis of the 2018 Nigeria HIV/AIDS Indicator and Impact Survey data showed significant discordance between the first and second tests, necessitating an evaluation of the algorithm. This manuscript highlights lessons learnt from that evaluation.Intervention: A two-phased evaluation method was employed, including abstraction and analysis of retrospective HIV testing data from January 2017 to December 2019 from 24 selected sites supported by the United States President’s Emergency Plan for AIDS Relief programme. A prospective evaluation of HIV testing was done among 2895 consecutively enrolled and consented adults, aged 15–64 years, accessing HIV testing services from three selected sites per state across the six geopolitical zones of Nigeria between July 2020 and September 2020. The prospective evaluation was performed both in the field and at the National Reference Laboratory under controlled laboratory conditions. Stakeholder engagements, strategic selection and training of study personnel, and integrated supportive supervision were employed to assure the quality of evaluation procedures and outcomes.Lessons learnt: The algorithm showed higher sensitivity and specificity in the National Reference Laboratory compared with the field. The approaches to quality assurance were integral to the high-quality study outcomes.Recommendations: We recommend comparison of testing algorithms under evaluation against a gold standard.What this study adds: This study provides context-specific considerations in using World Health Organization recommendations to evaluate the Nigerian national HIV rapid testing algorithm. | |
| Publisher | AOSIS | |
| Date | 2024-08-28 | |
| Identifier | 10.4102/ajlm.v13i1.2339 | |
| Source | African Journal of Laboratory Medicine; Vol 13, No 1 (2024); 7 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/2339/2953
https://ajlmonline.org/index.php/ajlm/article/view/2339/2954
https://ajlmonline.org/index.php/ajlm/article/view/2339/2955
https://ajlmonline.org/index.php/ajlm/article/view/2339/2958
https://ajlmonline.org/index.php/ajlm/article/view/2339/2956
|
|
ADVERTISEMENT
