Colonisation with multidrug-resistant organisms among dialysis patients at Universitas Academic Hospital
Southern African Journal of Infectious Diseases
| Field | Value | |
| Title | Colonisation with multidrug-resistant organisms among dialysis patients at Universitas Academic Hospital | |
| Creator | Shamhuyashe, Godknows van Zyl, Nicoline van Rooyen, Cornel Bisiwe, Feziwe Musoke, Jolly | |
| Description | Background: While most infections with multidrug-resistant organisms (MDROs) affect colonised people, there is limited evidence on MDRO colonisation in South African dialysis patients.Objectives: This study evaluated the prevalence of MDRO colonisation among dialysis patients, the resistance patterns of each MDRO and the risk factors for colonisation.Method: Rectal and nasal swabs were collected from dialysis patients who consented to participate in a 5-month study to identify selected MDROs (April 2021 – August 2021). Specimens were cultured on selected chromogenic media. Data collected included demographics, clinical information from medical records and laboratory results.Results: Multidrug-resistant organisms were isolated from 17 (23.9%) of the 71 enrolled participants. Of the 23 MDRO strains from rectal swabs (n = 71), extended-spectrum beta-lactamase-producing Enterobacterales accounted for 21.1% (15/71), vancomycin-resistant enterococci 2.8% (n = 2/71) and carbapenem-resistant Enterobacterales 4.2% (n = 3/71). Klebsiella pneumoniae (65.2%, n = 15/23) was the most prevalent MDRO. More than 80% resistance to trimethoprim and sulfamethoxazole, cefotaxine, and ciprofloxacin was noted. Significant risk factors included previous hospitalisation, proton pump inhibitor use and antibiotic exposure in the past 6 months.Conclusion: Multidrug-resistant organisms’ carriage was high in our dialysis population. The infection prevention and control measures need to be revised and strengthened.Contribution: This study falls within the scope of the SAJID journal as it is the first within sub-Sahara Africa to report that approximately one-fifth of dialysis patients were colonised with MDRO, which is a significant risk for MDRO infections. | |
| Publisher | AOSIS Publishing | |
| Date | 2024-07-09 | |
| Identifier | 10.4102/sajid.v39i1.607 | |
| Source | Southern African Journal of Infectious Diseases; Vol 39, No 1 (2024); 8 pages 2313-1810 2312-0053 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajid.co.za/index.php/sajid/article/view/607/1525
https://sajid.co.za/index.php/sajid/article/view/607/1526
https://sajid.co.za/index.php/sajid/article/view/607/1527
https://sajid.co.za/index.php/sajid/article/view/607/1528
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