Evaluation of serological assays for the diagnosis of HIV infection in adults
South African Family Practice
| Field | Value | |
| Title | Evaluation of serological assays for the diagnosis of HIV infection in adults | |
| Creator | Bangalee, Avania Bhoora, Sachin Punchoo, Rivak | |
| Description | Serological tests based on the enzyme immunoassay (EIA) are the primary tool for the diagnosis of human immunodeficiency virus (HIV) in adults and have rapidly evolved to quicker, affordable and more accurate test formats to detect early HIV infection. Second- and third-generation HIV rapid tests detect the immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies to the HIV and are used at the point of care and in HIV self-testing. The tests are affordable and accessible in state and private diagnostic laboratories. The present-day fourth- and fifth-generation EIAs can detect both p24 antigen and IgG and IgM HIV antibodies and thereby diagnose early HIV infection at approximately 2 weeks. The fourth- and fifth-generation EIAs also report sensitivity and specificity of more than 99%. The correct interpretation of HIV diagnosis of false-positive and false-negative EIA test results requires collaborative scrutiny of patient factors and laboratory test methodologies. | |
| Publisher | AOSIS | |
| Date | 2021-10-25 | |
| Identifier | 10.4102/safp.v63i1.5316 | |
| Source | South African Family Practice; Vol 63, No 1 (2021): Part 4; 5 pages 2078-6204 2078-6190 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://safpj.co.za/index.php/safpj/article/view/5316/6991
https://safpj.co.za/index.php/safpj/article/view/5316/6992
https://safpj.co.za/index.php/safpj/article/view/5316/6993
https://safpj.co.za/index.php/safpj/article/view/5316/6994
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