The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea
African Journal of Laboratory Medicine
| Field | Value | |
| Title | The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea | |
| Creator | Presser, Lance D. Coffin, Jeanette Koivogui, Lamine Campbell, Allan Campbell, Julian Barrie, Fatmata Ngobeh, Jone Souma, Zein Sorie, Samuel Harding, Doris Camara, Alimou Tohonamou, Pepe Traore, Basala Hamill, Frank A. Bogan, Joe Altmann, Sharon Ross, Casey Mansheim, Jay Hegerty, Robert Poynter, Scott Shearrer, Scott Asbun, Carmen Karlstrand, Brendan Davis, Phil Alam, Jane Roberts, David Stamper, Paul D. Ndjomou, Jean Wauquier, Nadia Koroma, Mohamed Munu, Alhaji McClintock, Jason Mar, Mar Burns, True Krcha, Stephen | |
| Description | Background: Ebola virus emerged in West Africa in December 2013. The ease of mobility, porous borders, and lack of public health infrastructure led to the largest Ebola virus disease (EVD) outbreak to date.Intervention: The 2013 EVD outbreak signalled the need for laboratory diagnostic capabilities in areas without strong public health systems. As part of the United States’ Department of Defense response, MRIGlobal was contracted to design, fabricate, equip, deploy, and operate two mobile diagnostic laboratories (MDLs). The first laboratory analysed blood samples from patients in an adjacent Ebola Treatment Centre (ETC) and buccal swabs from the deceased in the community in Moyamba, Sierra Leone. The second laboratory was deployed to support an ETC in Conakry, Guinea. The Department of Defense provided real-time quantitative reverse transcription polymerase chain reaction assays that were deployed and validated on-site.Lessons Learnt: Prompt and accurate molecular diagnostics reduced sample turn-around times from over 24 h to under 4 h. Experienced laboratory staff tested up to 110 samples per day and on-site engineering proved necessary for MDL setup and operation. As the Ebola response slowed, the sustainment of the MDLs’ operations was prioritised, including staff training and the transition of the MDLs to local governments. Training programmes for local staff were prepared in Sierra Leone and Guinea.Recommendations: The MRIGlobal MDL team significantly contributed to establishing increased laboratory capacity during the EVD outbreak in West Africa. Using the MDLs for molecular diagnosis is highly recommended until more sustainable solutions can be provided. | |
| Publisher | AOSIS | |
| Date | 2021-10-22 | |
| Identifier | 10.4102/ajlm.v10i1.1414 | |
| Source | African Journal of Laboratory Medicine; Vol 10, No 1 (2021); 6 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/1414/2060
https://ajlmonline.org/index.php/ajlm/article/view/1414/2061
https://ajlmonline.org/index.php/ajlm/article/view/1414/2062
https://ajlmonline.org/index.php/ajlm/article/view/1414/2063
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