Higher proportion of non-classical and intermediate monocytes in newly diagnosed multiple myeloma patients in Egypt: A possible prognostic marker
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Higher proportion of non-classical and intermediate monocytes in newly diagnosed multiple myeloma patients in Egypt: A possible prognostic marker | |
| Creator | Zahran, Asmaa M. Nafady-Hego, Hanaa Moeen, Sawsan M. Eltyb, Hanan A. Wahman, Mohammed M. Nafady, Asmaa | |
| Description | Background: Interaction between multiple myeloma (MM) cells and proximal monocytes is expected during plasma cell proliferation. However, the role of monocyte subsets in the disease progression is unknown.Objective: This study evaluated circulating monocyte populations in MM patients and their correlation with disease severity.Methods: Peripheral monocytes from 20 patients with MM attending Assiut University Hospital in Assiut, Egypt, between October 2018 and August 2019 were processed using a flow cytometry procedure and stratified using the intensity of expression of CD14 and CD16 into classical (CD16−CD14++), intermediate (CD16+CD14++), and non-classical (CD16++CD14+) subsets. The data were compared with data from 20 healthy control participants with comparable age and sex.Results: In patients with MM, the percentage of classical monocytes was significantly lower (mean ± standard error: 77.24 ± 0.66 vs 83.75 ± 0.5), while those of non-classical (12.44 ± 0.5 vs 8.9 ± 0.34) and intermediate (10.3 ± 0.24 vs 7.4 ± 0.29) monocytes were significantly higher when compared with those of controls (all p 0.0001). Proportions of non-classical and intermediate monocytes correlated positively with serum levels of plasma cells, M-protein, calcium, creatinine and lactate dehydrogenase, and correlated negatively with the serum albumin level. Proportions of classical monocytes correlated positively with albumin level and negatively correlated with serum levels of M-protein, plasma cells, calcium, creatinine, and lactate dehydrogenase.Conclusion: Circulating monocyte subpopulations are skewed towards non-classical and intermediate monocytes in MM patients, and the intensity of this skewness increases with disease severity. | |
| Publisher | AOSIS | |
| Date | 2021-08-25 | |
| Identifier | 10.4102/ajlm.v10i1.1296 | |
| Source | African Journal of Laboratory Medicine; Vol 10, No 1 (2021); 8 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/1296/2023
https://ajlmonline.org/index.php/ajlm/article/view/1296/2024
https://ajlmonline.org/index.php/ajlm/article/view/1296/2025
https://ajlmonline.org/index.php/ajlm/article/view/1296/2026
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