Indications and diagnostic value of bone marrow examination in HIV-positive individuals: A 3-year review at Tygerberg Hospital
Southern African Journal of Infectious Diseases
| Field | Value | |
| Title | Indications and diagnostic value of bone marrow examination in HIV-positive individuals: A 3-year review at Tygerberg Hospital | |
| Creator | Abdullah, Ibtisam Subramony, Nadhiya Musekwa, Ernest Nell, Erica-Mari Alzanad, Fatima Chetty, Carissa Gantana, Ethan Lohlun, Robert K. Cerfontein, Wardah Cochrane, Bridget Chapanduka, Zivanai C. | |
| Description | Background: Bone marrow examination is a useful diagnostic tool in human immunodeficiency virus (HIV)-positive patients presenting with cytopenias and fever. However, its role in the afebrile and asymptomatic patient presenting with an isolated cytopenia is not well established. This study was conducted to determine the indications for bone marrow examination and its diagnostic yield, in HIV-positive patients at Tygerberg Hospital.Methods: A retrospective, cross-sectional descriptive study was performed over a 3-year period from 01 September 2015 to 31 August 2018. The bone marrow examination reports for the HIV-positive patients who had a bone marrow examination during the study period were retrieved. Clinical and laboratory information was captured.Results: Altogether 374 bone marrow reports for HIV-positive patients were found. The indication of the bone marrow examination included investigation of unexplained cytopenias, suspected haematological malignancies, follow-up examination for patients with known haematological diseases, staging of haematological or non-haematological malignancies and investigation of suspected disseminated infection. The patients’ median age was 43 years and the interquartile range was 27–60 years. There was a slight female predominance with females 51% and males 49%. The diagnostic yield was 33.7%. Acute leukaemia and lymphoma were the most common diagnoses. Haematinic deficiency and pure red cell aplasia were found in the majority of cases with isolated anaemia. All cases with isolated thrombocytopenia were due to immune thrombocytopenia.Conclusion: Bone marrow examination is a useful investigation for HIV-positive patients with cytopenias, suspected haematological malignancy and lymphoma staging. However, its early use in patients with isolated anaemia and isolated thrombocytopenia is questionable. | |
| Publisher | AOSIS Publishing | |
| Date | 2021-08-23 | |
| Identifier | 10.4102/sajid.v36i1.273 | |
| Source | Southern African Journal of Infectious Diseases; Vol 36, No 1 (2021); 7 pages 2313-1810 2312-0053 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajid.co.za/index.php/sajid/article/view/273/709
https://sajid.co.za/index.php/sajid/article/view/273/710
https://sajid.co.za/index.php/sajid/article/view/273/712
https://sajid.co.za/index.php/sajid/article/view/273/713
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