Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)

Journal of the South African Veterinary Association


 
 
Field Value
 
Title Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)
 
Creator van der Weyden, Louise O'Dell, Nicolize Avenant, Alida Pazzi, Paolo Koeppel, Katja N.
 
Subject Veterinary Medicine, Wildlife lion; skin; cancer; radiation therapy; actinic damage; laminar fibrosis; UV
Description Cutaneous squamous cell carcinoma (SCC) is a slow growing but locally invasive neoplasm, most commonly caused by prolonged exposure to ultraviolet (UV) radiation. Whilst SCC accounts for 15% of skin tumours in domesticated cats, cutaneous SCC in non-domesticated felids (apart from captive snow leopards) appears to be uncommon, with only three reports in the literature to date. In this report, a captive African lion (Panthera leo) presented with two ulcerative lesions on the nasal planum. Histopathology of the lesions revealed epidermal keratinocyte dysplasia and neoplastic basal- and supra-basal epithelial cells with dyskeratosis and evidence of basement membrane breaching and dermal invasion, consistent with a diagnosis of SCC. There was also evidence of laminar fibrosis and inflammation of the subjacent dermis suggesting that the SCC most likely resulted from UV-induced neoplastic transformation of the epidermal squamous epithelium following actinic keratosis. The lion was treated with hypofractionated radiation therapy and remained in remission until his death (euthanised 17 months later because of age-related chronic renal failure). This is the first report of cutaneous SCC in a lion with evidence of actinic damage and resolution after radiation therapy.
 
Publisher AOSIS
 
Contributor
Date 2021-06-24
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — case report
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/jsava.v92i0.2134
 
Source Journal of the South African Veterinary Association; Vol 92 (2021); 6 pages 2224-9435 1019-9128
 
Language eng
 
Relation https://journals.jsava.aosis.co.za/index.php/jsava/article/view/2134/2713 https://journals.jsava.aosis.co.za/index.php/jsava/article/view/2134/2712 https://journals.jsava.aosis.co.za/index.php/jsava/article/view/2134/2714 https://journals.jsava.aosis.co.za/index.php/jsava/article/view/2134/2711
 
Coverage South Africa — wildlife
Rights Copyright (c) 2021 Louise van der Weyden, Nicolize O'Dell, Alida Avenant, Paolo Pazzi, Katja Natalie Koeppel https://creativecommons.org/licenses/by/4.0