Adult and paediatric haematology and clinical chemistry laboratory reference limits for Liberia
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Adult and paediatric haematology and clinical chemistry laboratory reference limits for Liberia | |
| Creator | Kieh, Mark W. Browne, Sarah M. Grandits, Greg A. Blie, Julie Doe-Anderson, Jestina W. Hoover, Marie L. Davis, Bionca Reilly, Cavan S. Neaton, James D. Lane, H. Clifford Kennedy, Stephen B. | |
| Description | Background: As more research is conducted in Liberia, there is a need for laboratory reference limits for common chemistry and haematology values based on a healthy population. Reference limits from the United States may not be applicable.Objective: The aim of this study was to present laboratory reference ranges from a Liberian population and compare them to United States ranges.Methods: Serum chemistry and haematology values from 2529 adults and 694 children and adolescents obtained from two studies conducted in Liberia between 2015 to 2017 were used to determine reference limits. After removing outliers, the reference limits defined by the 2.5th and 97.5th percentiles were determined by sex in three age groups (6–11, 12–17, and 18+ years).Results: The median (interquartile range) of adults was 29 (23, 37) years; 44% were female. The median (interquartile range) for children and adolescents was 12 (9, 15) years; 53% were female. Several reference ranges determined using Liberian participants differed from those in the US. For chemistries, a high percentage of both adults and children/adolescents had high serum chloride levels based on United States ranges. For haematology, a high percentage of Liberian participants had haemoglobin and related assays below the lower limit of United States ranges.Conclusion: Chemistry and haematology reference intervals determined for a Liberian population of healthy individuals should be considered for establishing eligibility criteria and monitoring of laboratory adverse events for clinical trials as well as for use in clinical settings in Liberia and perhaps for other countries in Western Africa. | |
| Publisher | AOSIS | |
| Date | 2020-11-25 | |
| Identifier | 10.4102/ajlm.v9i1.1080 | |
| Source | African Journal of Laboratory Medicine; Vol 9, No 1 (2020); 8 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/1080/1738
https://ajlmonline.org/index.php/ajlm/article/view/1080/1737
https://ajlmonline.org/index.php/ajlm/article/view/1080/1739
https://ajlmonline.org/index.php/ajlm/article/view/1080/1736
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