Developmental status of human immunodeficiency virus-exposed uninfected premature infants compared with premature infants who are human immunodeficiency virus unexposed and uninfected
South African Journal of Physiotherapy
| Field | Value | |
| Title | Developmental status of human immunodeficiency virus-exposed uninfected premature infants compared with premature infants who are human immunodeficiency virus unexposed and uninfected | |
| Creator | Cox, Charne Potterton, Joanne Rosie, Samantha | |
| Description | Background: There is growing concern about the developmental outcome of infants exposed to HIV in utero. HIV-infected women are at greater risk of premature delivery which poses a further developmental risk factor.Objectives: To determine whether there is a difference between the development of premature infants born at 28–37 weeks gestational age that are HIV exposed but uninfected (HEU) compared with HIV-unexposed uninfected infants (HUU).Method: A cross-sectional study was conducted in a Johannesburg state hospital. Thirty HEU and 30 HUU infants, aged between 16 days and six months, were assessed using the Bayley Scales of Infant and Toddler Development III.Results: The two groups were well matched for gestational age and birth weight; however, more HUU infants presented with neonatal complications. HUU infants had lower developmental scores than HEU infants in the language (p = 0.003) and motor (p = 0.037) subscales. Expressive language was more affected in the HUU infants (p = 0.001), and fine (p = 0.001) and gross motor (p = 0.03) were affected as well. HUU infants with neonatal complications such as meningitis (p = 0.02) and neonatal jaundice (NNJ) (p = 0.01) are more likely to present with language and motor delay.Conclusion: Meningitis and NNJ have more impact on infant development than in-utero HIV and ARV exposure.Clinical implications: It is important for all premature infants to be screened regularly in order to diagnose developmental delays early so as to ensure early intervention and improved quality of life. | |
| Publisher | AOSIS | |
| Date | 2020-06-18 | |
| Identifier | 10.4102/sajp.v76i1.1401 | |
| Source | South African Journal of Physiotherapy; Vol 76, No 1 (2020); 6 pages 2410-8219 0379-6175 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajp.co.za/index.php/sajp/article/view/1401/2060
https://sajp.co.za/index.php/sajp/article/view/1401/2059
https://sajp.co.za/index.php/sajp/article/view/1401/2061
https://sajp.co.za/index.php/sajp/article/view/1401/2058
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