Blood acid–base, haematological and haemostatic effects of hydroxyethyl starch (130/0.4) compared to succinylated gelatin colloid infusions in normovolaemic dogs

Journal of the South African Veterinary Association


 
 
Field Value
 
Title Blood acid–base, haematological and haemostatic effects of hydroxyethyl starch (130/0.4) compared to succinylated gelatin colloid infusions in normovolaemic dogs
 
Creator Buck, Roxanne K. Bester, Lynette Boustead, Keagan J. Kadwa, Abdur R. Zeiler, Gareth E.
 
Subject veterinary acid–base balance; coagulation; Gelofusine; synthetic colloids; Voluven; full blood count (FBC); complete blood count (CBC)
Description Synthetic colloids are commonly administered to dogs to treat absolute or relative hypovolaemia. Voluven® (tetrastarch 130/0.4) and Gelofusine® (succinylated gelatin) are available to veterinarians in South Africa. In humans, use of these products has caused acid–base derangements, changes in haematology and impaired haemostasis. We aimed to investigate these effects in healthy normovolaemic dogs. Eight healthy adult beagle dogs underwent a cross-over study, receiving Voluven® or Gelofusine® (10 mL/kg/h for 120 min) once each with a 14-day washout between treatments. Dogs were premedicated with dexmedetomidine (10 µg/kg intramuscularly). Anaesthesia was induced with propofol and the dogs were maintained with isoflurane-in-oxygen. The anaesthetised dogs were connected to a multi-parameter monitor to monitor physiological parameters throughout. Catheters placed in a jugular vein and dorsal metatarsal artery allowed sampling of venous and arterial blood. Blood was collected immediately prior to commencement of colloid infusion, after 60 min infusion and at the end of infusion (120 min) to allow for arterial blood gas analysis, haematology and coagulation testing (activated partial thromboplastin time [aPTT], prothrombin time [PT] and thromboelastography [TEG]). There was no effect, between treatments or over time, on blood pH. The haemoglobin concentration, erythrocyte count and haematocrit decreased significantly over time (all p 0.01), with no differences between treatments, and remained within normal clinical ranges. There were no differences between treatments or over time for the TEG, aPTT and PT tests of haemostasis. At the dose studied, Voluven® and Gelofusine® had comparably negligible effects on blood acid–base balance and coagulation in normovolaemic dogs.
 
Publisher AOSIS
 
Contributor
Date 2020-06-04
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — crossover study
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/jsava.v91i0.1990
 
Source Journal of the South African Veterinary Association; Vol 91 (2020); 9 pages 2224-9435 1019-9128
 
Language eng
 
Relation https://jsava.co.za/index.php/jsava/article/view/1990/2539 https://jsava.co.za/index.php/jsava/article/view/1990/2538 https://jsava.co.za/index.php/jsava/article/view/1990/2540 https://jsava.co.za/index.php/jsava/article/view/1990/2537
 
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Rights Copyright (c) 2020 Roxanne K. Buck, Lynette Bester, Keagan J. Boustead, Abdur R. Kadwa, Gareth E. Zeiler https://creativecommons.org/licenses/by/4.0