How much variance in insulin resistance is explained by obesity?
Journal of Metabolic Health (previously Journal of Insulin Resistance)
| Field | Value | |
| Title | How much variance in insulin resistance is explained by obesity? | |
| Creator | Vidwans, Harshada B. Watve, Milind G. | |
| Description | Background: Obesity is believed to be the major cause of insulin resistance, although many other obesity-independent signals are shown to affect insulin sensitivity.Aim: We address the degree to which variation in insulin resistance is explained by morphometric and biochemical measures of obesity.Methods: PubMed and Google Scholar were searched for epidemiological studies published between 1994 and 2015 that report correlations between at least one measure of obesity and that of insulin resistance.Results: A total of 63 studies satisfied inclusion criteria. Frequency distribution of coefficients of determination between morphometric measures of obesity and insulin resistance was skewed with the mode being less than 10%, class and median being 17.3%. Plasma leptin concentration, but not plasma non-esterified fatty acid level, was better correlated with insulin resistance, the median variance explained being 33.29%. Morphometric measures alone had a median variance explained of 16%. Ethnicity explained part of the variance across studies with the correlation being significantly poorer in Asians.Conclusion: The extremely limited predictive power of morphometric and biochemical measures of obesity suggests that more research needs to focus on the obesity-independent signals that affect insulin sensitivity as well as leptin expression. | |
| Publisher | AOSIS | |
| Date | 2017-06-27 | |
| Identifier | 10.4102/jir.v2i1.22 | |
| Source | Journal of Insulin Resistance; Vol 2, No 1 (2017); 7 pages 2519-7533 2412-2785 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://insulinresistance.org/index.php/jir/article/view/22/49
https://insulinresistance.org/index.php/jir/article/view/22/50
https://insulinresistance.org/index.php/jir/article/view/22/51
https://insulinresistance.org/index.php/jir/article/view/22/48
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