The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency

Journal of Insulin Resistance


 
 
Field Value
 
Title The fructose–copper connection: Added sugars induce fatty liver and insulin resistance via copper deficiency
 
Creator DiNicolantonio, James J. Mangan, Dennis O'Keefe, James H.
 
Subject — copper; fructose; sucrose; sugar; fatty liver
Description Background: Evidence suggests that the overconsumption of added sugars can induce fatty liver disease and insulin resistance.Aim: To propose a hypothesis that added sugars induce copper deficiency which can lead to hepatic iron overload, fatty liver disease, insulin resistance and eventually non-alcoholic steatohepatitis.Setting: On average, the intake of added sugars in humans is higher than levels that have been found to impair copper status in animals.Methods: Narrative review.Results: Fructose-induced copper deficiency may be a leading cause of fatty liver disease and insulin resistance.Conclusion: The reduction in the intake of added sugars may improve copper status and reduce the risk of fatty liver disease and insulin resistance.
 
Publisher AOSIS
 
Contributor
Date 2018-09-26
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip application/xml application/pdf
Identifier 10.4102/jir.v3i1.43
 
Source Journal of Insulin Resistance; Vol 3, No 1 (2018); 3 pages 2519-7533 2412-2785
 
Language eng
 
Relation https://insulinresistance.org/index.php/jir/article/view/43/142 https://insulinresistance.org/index.php/jir/article/view/43/140 https://insulinresistance.org/index.php/jir/article/view/43/141 https://insulinresistance.org/index.php/jir/article/view/43/139
 
Coverage — — —
Rights Copyright (c) 2018 James J. DiNicolantonio https://creativecommons.org/licenses/by/4.0