Does adjunctive use of metronidazole plus amoxicillin benefit patients receiving non-surgical scaling and root planing for the treatment of generalised aggressive periodontitis?

Open Journal of Implant Dentistry


 
 
Field Value
 
Title Does adjunctive use of metronidazole plus amoxicillin benefit patients receiving non-surgical scaling and root planing for the treatment of generalised aggressive periodontitis?
 
Creator van Zyl, Andre W. Hartshorne, Johan Carrasco-Labra, Alonso
 
Subject — amoxicillin; antibiotic treatment; generalised aggressive periodontitis; metronidazole; scaling and root planning
Description This article describes a double-blinded, placebo-controlled randomised clinical trial thatinvolved 30 eligible subjects experiencing generalised aggressive periodontitis. Subjectswere randomly assigned to either the test group (scaling and root planing + metronidazole[400 mg]) and amoxicillin [500 mg]) or the control group (scaling and root planing withoutthe adjunctive antibiotics combination). Both antibiotics and placebos were administeredthree times per day for 14 days. Participants were examined at baseline, and again six monthsand one year after therapy. Both therapies led to a statistically significant improvementin all clinical parameters as measured after one year. However, subjects who received themetronidazole–amoxicillin combination showed the greatest reduction in mean probingdepth, an improved clinical attachment level and a lower mean number of residual sitesafter one year. The investigators concluded that the non-surgical treatment of generalisedaggressive periodontitis was markedly improved by the adjunctive use of metronidazole andamoxicillin up to one year after treatment.
 
Publisher AOSIS
 
Contributor
Date 2013-03-26
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/octet-stream text/xml application/pdf
Identifier 10.4102/ojid.v1i1.7
 
Source Open Journal of Implant Dentistry; Vol 1, No 1 (2013); 3 pages 2226-4507 n/a
 
Language eng
 
Relation https://ojid.org/index.php/ojid/article/view/7/18 https://ojid.org/index.php/ojid/article/view/7/19 https://ojid.org/index.php/ojid/article/view/7/20 https://ojid.org/index.php/ojid/article/view/7/17
 
Coverage — — —
Rights Copyright (c) 2013 Andre W. van Zyl, Johan Hartshorne, Alonso Carrasco-Labra https://creativecommons.org/licenses/by/4.0