Emtricitabine-induced pure red cell aplasia
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Emtricitabine-induced pure red cell aplasia | |
| Creator | Manickchund, Nithendra du Plessis, Camille John, Melanie-Anne A. Manzini, Thandekile C. Gosnell, Bernadett I. Lessells, Richard J. Moosa, Yunus S. | |
| Description | Introduction: Anemia is common in HIV. Parvo B19 infection is a well-recognised cause of red cell aplasia. Other causes of persistent pure red cell aplasia (PRCA) include anti-retroviral drugs such as zidovudine and lamivudine. We describe a case of PRCA that strongly implicates emtricitabine as the probable cause.Patient presentation: Patient was HIV positive and on treatment with a fixed drug combination consisting of tenofovir, emtricitabine and efavirenz for 3 months when she developed severe transfusion dependent anemia. The anemia, attributed to PRCA, was persistent and transfusion dependent for about one year.Management and outcome: Replacement of emtricitabine with abacavir resulted in a prompt, complete and lasting resolution of the anaemia, suggesting an etiologic role of emtricitabine in the PRCA.Conclusion: Emtricitibine is a rare cause of pure red cell aplasia. | |
| Publisher | AOSIS | |
| Date | 2019-09-23 | |
| Identifier | 10.4102/sajhivmed.v20i1.983 | |
| Source | Southern African Journal of HIV Medicine; Vol 20, No 1 (2019); 3 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/983/1602
https://sajhivmed.org.za/index.php/hivmed/article/view/983/1601
https://sajhivmed.org.za/index.php/hivmed/article/view/983/1603
https://sajhivmed.org.za/index.php/hivmed/article/view/983/1600
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