B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients | |
| Creator | Flepisi, Brian T. Bouic, Patrick Sissolak, Gerhard Rosenkranz, Bernd | |
| Description | Background: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased T-cell turnover and lymph node fibrosis.Objectives: This study aimed to determine the serum levels of circulating B-cell activation markers, and the expression of T-cell activation and regulatory markers in HIV-positive NHL patients.Method: The serum levels of circulating soluble(s) sCD20, sCD23, sCD27, sCD30 and sCD44 molecules, all of which are biomarkers of B-cell activation, were determined by enzyme-linked immunosorbent assays (ELISA), while biomarkers of T-cell activation (CD8+CD38+) and regulation (FoxP3) were determined by flow cytometry in 141 subjects who were divided into five groups: Combination antiretroviral therapy (ART)-naïve HIV-positive patients; ART-treated HIV-positive patients; HIV-negative NHL patients; HIV-positive NHL patients on ART; and healthy controls.Results: HIV-positive NHL patients had significantly higher serum levels of sCD20, sCD23, sCD30 and sCD44 than HIV-negative NHL patients, while all five biomarkers were significantly elevated in HIV-positive NHL patients when compared with ART-treated HIV-positive patients. HIV-positive NHL patients had higher CD8+CD38+ and lower FoxP3 expression than HIV-negative NHL and ART-treated HIV-positive patients.Conclusion: B-cell activation is increased in HIV-positive NHL patients and is associated with reduced regulatory T-cell populations and increased CD8+ T-cell activation. | |
| Publisher | AOSIS | |
| Date | 2018-11-07 | |
| Identifier | 10.4102/sajhivmed.v19i1.809 | |
| Source | Southern African Journal of HIV Medicine; Vol 19, No 1 (2018); 7 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/809/1294
https://sajhivmed.org.za/index.php/hivmed/article/view/809/1293
https://sajhivmed.org.za/index.php/hivmed/article/view/809/1295
https://sajhivmed.org.za/index.php/hivmed/article/view/809/1292
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