Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Hypertriglyceridaemia and the risk of pancreatitis six months post lopinavir/ritonavir initiation | |
| Creator | Greffrath, Wilhelm P. du Plessis, Jesslee M. Viljoen, Michelle Cockeran, Marike | |
| Description | Background: Hypertriglyceridaemia (HTG) is an important risk factor for pancreatitis and cardiovascular disease (CVD), depending on severity. Hypertriglyceridaemia is common in human immunodeficiency virus (HIV) infection and is also a common complication of lopinavir/ritonavir (LPV/r).Objectives: To evaluate the risk of pancreatitis associated with HTG in patients six months post initiation of LPV/r-based therapy in a regional public hospital.Methods: Triglyceride (TG), serum amylase (s-amylase) and CD4+ count values were retrospectively investigated six months post LPV/r-based initiation. Age, gender, previous antiretroviral regimen and period since HIV diagnosis were also recorded.Results: The final sample consisted of 194 patients, 50 males and 144 females; mean (± standard deviation [s.d.]) age was 39.52 (± 9.98) years, and the mean (± s.d.) period since HIV diagnosis was 91.32 (± 25.18) months. Normal TG levels ( 1.70 mmol/L) were detected in only 55% of patients and the rest presented with some degree of HTG. The mean (± s.d.) TG for the entire sample was elevated at 1.94 (± 1.30) mmol/L with the mean (± s.d.) of the males at 2.36 (± 1.74) – statistically higher compared to the females at 1.79 (± 1.08) mmol/L (p = 0.034). No cases of pancreatitis were recorded and the time since HIV diagnosis did not indicate any statistically significant differences in the means of the TG, serum amylase or CD4 count values.Conclusion: Triglyceride levels were not substantially elevated to induce pancreatitis at six months post initiation of LPV/r, but were elevated above the accepted upper normal limit of 1.70 mmol/L which may have implications for cardiovascular risk. | |
| Publisher | AOSIS | |
| Date | 2018-06-26 | |
| Identifier | 10.4102/sajhivmed.v19i1.766 | |
| Source | Southern African Journal of HIV Medicine; Vol 19, No 1 (2018); 6 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/766/1187
https://sajhivmed.org.za/index.php/hivmed/article/view/766/1186
https://sajhivmed.org.za/index.php/hivmed/article/view/766/1188
https://sajhivmed.org.za/index.php/hivmed/article/view/766/1185
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