Investigation of the growth patterns of non-functioning pituitary macroadenomas using volumetric assessments on serial MRI investigations

SA Journal of Radiology


 
 
Field Value
 
Title Investigation of the growth patterns of non-functioning pituitary macroadenomas using volumetric assessments on serial MRI investigations
 
Creator Pieterse, Jaco de Vries, Coert S. Otto, Susanna F.
 
Subject — —
Description Background: Benign non-functioning pituitary macroadenomas (NFMA) often cause mass effect on the optic chiasm necessitating transsphenoidal surgery to prevent blindness.However, surgery is complicated and there is a high tumour recurrence rate. Currently, very little is known about the natural (and residual post-surgical) growth patterns of these NFMA. Conflicting data describe decreased growth to exponential growth over various time periods.Due to lack of information on growth dynamics of these NFMA, suitable follow-up imaging protocols have not been described to date.Objective: To determine if NFMA grow or stay quiescent over a time period using serial MRI investigations and a stereo logical method to determine tumour volume. In addition, to evaluate if NFMA adhere to a certain growth pattern or grow at random.Method: Thirteen patients with NFMA had serial MRI investigations over a 73-month period at the Universitas Academic Hospital. Six of the selected patients had undergone previous surgery, while seven patients had received no medical or surgical intervention. By using astereological method, tumour volumes were calculated and plotted over time to demonstrate growth curves. The data were then fitted to tumour growth models already described in literature in order to obtain the best fit by calculating the r2 value.Results: Positive tumour growth was demonstrated in all cases. Tumour growth patterns of nine patients best fitted the exponential growth curve while the growth patterns of three patients best fitted the logistic growth curve. The remaining patient demonstrated a linear growth pattern.Conclusion: A specific growth model best described tumour growth observed in non-surgical and surgical cases. If follow-up imaging confirms positive growth, future growth can be predicted by extrapolation. This information can then be used to determine the relevant follow-up-imaging interval in each individual patient.
 
Publisher AOSIS
 
Contributor
Date 2016-07-28
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/octet-stream text/xml application/pdf
Identifier 10.4102/sajr.v20i1.962
 
Source South African Journal of Radiology; Vol 20, No 1 (2016); 7 pages 2078-6778 1027-202X
 
Language eng
 
Relation https://sajr.org.za/index.php/sajr/article/view/962/1210 https://sajr.org.za/index.php/sajr/article/view/962/1211 https://sajr.org.za/index.php/sajr/article/view/962/1212 https://sajr.org.za/index.php/sajr/article/view/962/1207
 
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Rights Copyright (c) 2016 Jaco Pieterse, Coert S. de Vries, Susanna F. Otto https://creativecommons.org/licenses/by/4.0