Inter-observer variability influences the Lugano classification when restaging lymphoma
SA Journal of Radiology
| Field | Value | |
| Title | Inter-observer variability influences the Lugano classification when restaging lymphoma | |
| Creator | Möller, Jacobus Steyn, Tiaan Combrinck, Nantes Joubert, Gina Sherriff, Alicia Janse van Rensburg, Jacques | |
| Description | Background: Lymphoma is an important and potentially curable oncological disease in South Africa. The staging and restaging of lymphoma have evolved over the years, with the latest international consensus guideline being the Lugano classification (LC). Prior to routine implementation of the LC, its robustness in the local setting should be determined. Objectives: To determine the Inter-observer variability in response assignment when applying the LC in patients with lymphoma who were staged and restaged with computed tomography. In case of excessive discordance, specific mitigating measures will have to be taken before and during any proposed implementation of the LC. Method: A total of 61 computed tomography scans in 21 patients were evaluated independently by four reviewers according to the LC, of which 21 scans were done at baseline, 21 at initial restaging and 19 at follow-up restaging. A retrospective comparative analysis was performed. Kappa values were calculated to determine agreement between observers. Results: Only a moderate inter-observer agreement of 52% in the overall response classification was demonstrated. The most important sources of discrepancy were inconsistency in the assessment of target lesion regression to normal, determining the percentage change in the summed cross-sectional area of the target lesions and ascribing new lesions as either due to lymphoma or other causes. Conclusion: Implementing the Lugano classification when restaging lymphoma is desirable to improve consistency and to conform to international guidelines. However, our study shows substantial inter-observer variability in response classification, potentially altering the treatment plan. Dedicated training and continuous quality control should, therefore, accompany the process. | |
| Publisher | AOSIS | |
| Date | 2018-07-31 | |
| Identifier | 10.4102/sajr.v22i1.1357 | |
| Source | South African Journal of Radiology; Vol 22, No 1 (2018); 8 pages 2078-6778 1027-202X | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajr.org.za/index.php/sajr/article/view/1357/1882
https://sajr.org.za/index.php/sajr/article/view/1357/1881
https://sajr.org.za/index.php/sajr/article/view/1357/1883
https://sajr.org.za/index.php/sajr/article/view/1357/1880
|
|
ADVERTISEMENT
