Multi-voxel proton magnetic resonance spectroscopy changes in neuropsychiatric lupus patients

SA Journal of Radiology


 
 
Field Value
 
Title Multi-voxel proton magnetic resonance spectroscopy changes in neuropsychiatric lupus patients
 
Creator Wang, Page l. Harris, Richard E. Chenevert, Thomas L. McCune, William J. Sundgren, Pia C.
 
Subject radiology; rheumatology systemic lupus erythematosus; SLE; neuropsychiatric systemic lupus erythematosus; NPSLE; spectroscopy
Description Purpose: In this prospective study, we used 2D chemical shift imaging (CSI), a multi-voxel proton spectroscopy technique, to evaluate the brain metabolites on conventional magnetic resonance imaging (MRI) in normal-appearing white and grey matter in systemic lupus erythematosus (SLE) patients with neuropsychiatric symptoms (NPSLE); without neuropsychiatric symptoms (non-NPSLE); and healthy controls (HCs). Our objective was to find metabolites that discriminated NPSLE patients from the non-NPSLE and HC cohorts.Materials and methods: The study included 23 NPSLE patients, 20 non-NPSLE patients, and 21 HCs. A clinical assessment including the SLE disease activity index (SLEDAI) and systemic lupus international collaborating clinics (SLICC) scores was conducted. All patients underwent conventional MRI and 2D CSI technique to acquire the following metabolic ratios: NAA/Cr, Cho/Cr, and Cho/NAA in the anterior and posterior insula, anterior frontal and parietal white and grey matter, thalamus, basal ganglia, and occipital grey matter.Results: In terms of metabolic differences, the NPSLE patients had significant differences compared with the non-NPSLE and HC groups in the: left posterior insula (increased Cho/NAA; p = 0.008), right internal capsule (increased Cho/Cr; p 0.05), left thalamus (increased NAA/Cr; p = 0.011), anterior grey matter (increased NAA/Cr; p = 0.004), posterior grey matter (increased Cho/NAA; p = 0.016), anterior white matter (increased NAA/Cr; p = 0.012), and left posterior white matter (increased Cho/NAA; p = 0.022). The NPSLE patients showed significantly higher SLEDAI scores (p 0.001).Conclusion: We found several significant distinct metabolic differences between NPSLE and non-NPSLE/HC patients in various brain locations.Keywords: systemic lupus erythematosus; SLE; neuropsychiatric systemic lupus erythematosus; NPSLE; spectroscopy
 
Publisher AOSIS
 
Contributor Department of Radiology Seed Grant U008039, the MICHR UL1RR024986, Skåne University Foundation, Sweden, and Rheumatology Foundation, Sweden.
Date 2016-06-14
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — prospective
Format text/html application/octet-stream text/xml application/pdf
Identifier 10.4102/sajr.v20i1.974
 
Source South African Journal of Radiology; Vol 20, No 1 (2016); 5 pages 2078-6778 1027-202X
 
Language eng
 
Relation https://sajr.org.za/index.php/sajr/article/view/974/1185 https://sajr.org.za/index.php/sajr/article/view/974/1186 https://sajr.org.za/index.php/sajr/article/view/974/1187 https://sajr.org.za/index.php/sajr/article/view/974/1165
 
Coverage — — 23-69; female > male
Rights Copyright (c) 2016 Page l. Wang, Richard E. Harris, Thomas L. Chenevert, William J. McCune, Pia C. Sundgren https://creativecommons.org/licenses/by/4.0