Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy
African Vision and Eye Health
| Field | Value | |
| Title | Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy | |
| Creator | Goodman, Megan B. Ziskind, Ari | |
| Description | Purpose: To determine the sensitivity of spectral domain ocular coherence tomography (SD-OCT) and fundus auto fluorescence (FAF) images as a screening test to detect early changes in the retina prior to the onset of chloroquine retinopathy.Method: The study was conducted using patients taking chloroquine (CQ), referred by the Rheumatology Department to the Ophthalmology Department at Tygerberg Academic Hospital. Group A consisted of 59 patients on CQ for less than 5 years, and Group B consisted of 53 patients on CQ for more than 5 years. A 200 × 200 macula thickness map, 5-line raster SD-OCT on a Carl Zeiss Meditec Cirrus HD-OCT and FAF images on a Carl Zeiss Meditec Visucam 500 were recorded for 223 eyes. Images were reviewed independently, and then those of Groups A and B compared.Results: There were no statistically significant differences between Groups A and B. The criteria included the internal limiting membrane and the retinal pigment epithelium (ILM-RPE) thickness, interdigitation zone integrity (p = 0.891, df = 1, χ² = 0.1876), ellipsoid zone integrity (p = 0.095, df = 2, χ² = 4.699) and FAF image irregularities (p = 0.479, df = 1, χ²= 4995978).Conclusion: The inclusion of SD-OCT and FAF as objective tests into the prescribed screening guidelines does not appear to simplify the detection of subclinical injury in patients on chloroquine treatment. | |
| Publisher | AOSIS | |
| Date | 2015-08-21 | |
| Identifier | 10.4102/aveh.v74i1.297 | |
| Source | African Vision and Eye Health; Vol 74, No 1 (2015); 5 pages 2410-1516 2413-3183 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://avehjournal.org/index.php/aveh/article/view/297/398
https://avehjournal.org/index.php/aveh/article/view/297/399
https://avehjournal.org/index.php/aveh/article/view/297/401
https://avehjournal.org/index.php/aveh/article/view/297/367
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