Detection and characterisation of papillomavirus in skin lesions of giraffe and sable antelope in South Africa
Journal of the South African Veterinary Association
Field | Value | |
Title | Detection and characterisation of papillomavirus in skin lesions of giraffe and sable antelope in South Africa | |
Creator | van Dyk, E. Bosman, A-M van Wilpe, E. Williams, J. H. Bengis, R. G. van Heerden, J. Venter, E. H. | |
Description | Papillomavirus was detected electron microscopically in cutaneous fibropapillomas of a giraffe (Giraffa camelopardalis) and a sable antelope (Hippotragus niger). The virus particles measured 45 nm in diameter. Histopathologically, the lesions showed histopathological features similar to those of equine sarcoid as well as positive immunoperoxidase-staining of tissue sections for papillomavirus antigen. Polymerase chain reaction (PCR) detected bovine papillomavirus (BPV) DNA. Bovine papillomavirus-1 was characterised by real-time PCR in the sable and giraffe, and cloning and sequencing of the PCR product revealed a similarity to BPV-1. As in the 1st giraffe, the lesions from a 2nd giraffe revealed locally malignant pleomorphism, possibly indicating the lesional end-point of papilloma infection. Neither virus particles nor positively staining papillomavirus antigen could be demonstrated in the 2nd giraffe but papillomavirus DNA was detected by real-time PCR which corresponded with BPV-1 and BPV-2. | |
Publisher | AOSIS | |
Date | 2011-04-11 | |
Identifier | 10.4102/jsava.v82i2.39 | |
Source | Journal of the South African Veterinary Association; Vol 82, No 2 (2011); 80-85 2224-9435 1019-9128 | |
Language | eng | |
Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://jsava.co.za/index.php/jsava/article/view/39/26
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